He made sure the ball got over the fence when he stepped up to the plate in the eighth.
Donaldson, Bautista and Martin all connected off right-hander Asher Wojciechowski in the fourth.
RED SOX 4, WHITE SOX 1: In Chicago, Pablo Sandoval hit a tiebreaking single in Boston's four-run sixth inning and Drew Pomeranz struck out eight in his second straight victory.
Tulowitzki's second homer of the season - and fourth grand slam of his career - put a charge in the Rogers Centre crowd of 29,844.
Toronto (25-27) has won seven of its last eight games and improved to 4-1 on its 10-game homestand. The Blue Jays go for their eighth win in the last nine games Wednesday when they eye a three-game sweep of the Reds.
As Blue Jays' announcer Buck Martinez pointed out immediately on the call, Donaldson's 435-foot blast reached the fifth deck at Rogers Centre.
The Reds' Tucker Barnhart had a one-out single and then, when Ryan Goins took his eye off the ball and made an error in his bid to finish off a double play, went to third with Jose Peraza at first and one out.
Pillar did make an appearance, however, coming in as a pinch-hitter for left fielder Chris Coghlan in the seventh inning and grounding out.
"We had a hard time keeping them in the ballpark this series", Reds manager Bryan Price said.
It was the second homer in as many days for Votto, his 14th overall this season, his pair of ribbies brings him into a tie for 5th in all Major League Baseball with 42 on the season, and his walk was his MLB-best 39th of the year.
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During the 2016 season, no matter how bad your team's bullpen was, you could always say, "Hey, at least we're not the Reds".
Cincinnati Reds first baseman Joey Votto hits a two-run home run against the Toronto Blue Jays during first inning interleague baseball action in Toronto on Wednesday, May 31, 2017. Happ went on the disabled list April 17 with elbow inflammation.
"It was a battle and I expected that", said Happ, who last pitched April 16.
The Yankees have their old swagger back and are perched on top of the American League East, the biggest surprise in baseball after winning 30 of their first 49 games. But I was able to settle down after those couple runs in the first and got out of a couple jams.
"I think each and every day our guys get more confidence because of the way we've been playing".
After back-to-back seasons of success, and relatively good health, it felt like the Jays were suffering through a year's worth of ups and (mostly) downs in one month.
After giving up three more runs in the fourth and fifth, Stephenson exited with 10 hits in two innings of work, allowing seven runs (six earned) in the process. It scored Schebler, who led off with a walk, advanced to second on a walk to Scooter Gennett and took third when Tucker Barnhart grounded into a double play.
Things have changed since the last time the Toronto Blue Jays played the New York Yankees. Tuesday night's homer was just his third so far this year, but keep in mind he missed six weeks with a calf injury.
Nearly incredibly after that stunning 2-11 start, they now have a 26-27 record and are red-hot and ready for the American League East-leading New York Yankees, who are coming to town for a four-game weekend series. The Blue Jays optioned reliever Dominic Leone to triple-A Buffalo to make room for Happ on the roster.
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